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In obese mouse models, liraglutide improved insulin sensitivity in visceral adipose tissue, which was associated with reduced endoplasmic reticulum stress and increased Akt phosphorylation following insulin stimulation ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets

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Therefore, single-drug therapy may be insufficient to address complex sarcopenia

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Severe but Rare Complications of GLP-1 and Peptide Therapy Pancreatitis and Gallbladder Problems Some studies suggest a link between GLP-1 therapies and acute pancreatitis or gallstones