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While this has been done in research settings, it is not practical for routine clinical therapy

AAV vectors are generally safe at therapeutic doses eight AAV-based gene therapies have been FDA-approved as of 2024 but at high doses, above roughly 10^14 viral genomes per kilogram, the literature documents immune reactions, liver toxicity, and in rare cases, genotoxicity

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Sample processing for protein extraction and tandem LysC/trypsin digestion Cell pellets (510 million cells) were lysed in an 8 M urea buffer with protease and phosphatase inhibitors