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Biologically plausible domain of applicability All the key events described should be conserved among animal species, suggesting that the AOP may also have relevance for amphibians, reptiles, birds and and invertebrates with sexual reproduction

For the cyanocobalamin component, while generally considered safe with few absolute contraindications, certain conditions warrant caution

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Several studies for protecting neurons by manipulating astrocytes have been revealed to be effective, and the role of astrocytes as both neuroprotective and exacerbating injury in ICH was reviewed recently (Barreto et al., 2011