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You lose that capacity

@KevinYTChen, a brilliant @GSKGradSchool graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: As we all know, immune checkpoint inhibitors have shown variable efficacy in patients with cancer

Pyruvate is metabolized to lactate in the cytosol or converted to acetyl coenzyme A (acetyl-CoA) in the mitochondria to fuel the tricarboxylic acid (TCA) cycle, enhance OXPHOS, and generate ATP [18,19]

Singh RH, Rohr F, Frazier D et al