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Hypersensitivity reactions Serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with semaglutide Avoid use in patients with known hypersensitivity to semaglutide and use caution in patients with a history of reactions to other GLP-1 analogs Semaglutide antibodies Semaglutide can induce an immune response that leads to the production of anti-semaglutide antibodies, and in some cases, these antibodies cross-react with endogenous GLP-1 In trials, 2.9% of Wegovy-treated patients developed anti-semaglutide antibodies, and of these patients, 56% had antibodies that cross-reacted with endogenous GLP-1

GLP-1 receptor agonists increase resting heart rate

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Semaglutide doesnt increase or decrease estrogen

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It has also been mentioned in related studies that ICA can also increase the expression of some enzymes in the glycolytic pathway, such as phosphoglycerate kinase 1 (PGK1) (94, 169)