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As treatment continued, there is a significant decrease in the number of EMPs, indicating reduced endothelial damage and improved vascular repair processes ( Moreover, intermittent fasting (IF), as a metabolic intervention strategy, has been extensively studied and has been shown to significantly improve body weight, lipid profiles, and blood pressure, thereby reducing the risk of CVDs (Kazeminasab et al., 2024)

Melatonin stimulates glucagon secretion in vitro and in vivo

Week 1: 6 units (0.3 mg) daily Week 2: 8 units (0.4 mg) daily Week 3: 10 units (0.5 mg) daily Week 4: 12 units (0.6 mg) daily During this phase, most patients notice improved sleep and mild energy increases

Therefore, results for sleep parameters are given as mean SD

doi: 10.1038/nprot.2012.024

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