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human antibodies Given the need for therapeutic specific human antibodies that block angiogenesis, human antibodies have been identified that are reactive against an epitope on VEGF that specifically and substantially blocks its interaction with VEGF receptor 2 (VEGFR2, KDR/Flk-1), but does not substantially blocks its interaction with VEGF receptor 1 (VEGFRl 5 FIt-I)

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