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Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15

The American Diabetes Association guidelines support continued use of medications that effectively manage blood glucose and provide additional benefits such as weight loss and cardiovascular protection, with regular reassessment of treatment goals and tolerability

Tambin est indicado para reducir el riesgo de eventos cardiovasculares adversos mayores en adultos con sobrepeso u obesidad y enfermedad cardiovascular establecida

While mild muscle discomfort during weight loss may not require immediate medical attention, certain features warrant prompt clinical evaluation to exclude serious underlying conditions

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Semaglutide GLP-1 is also not recommended for individuals with a history of severe gastrointestinal disease or gastroparesis, as it may exacerbate these conditions