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Its 670-person Phase 3 trial is will finish in June 2026, but the company has not yet announced when they expect to report the results

ROS are reported to cause oxidation of the catalytic cysteine residue at the active site of E1 and E2 enzymes and promote the formation of E1/E2-containing disulfide complexes, which prevents these enzymes from catalyzing ubiquitination [note: this would decrease levels of ubiquitin conjugates] (Hunter, 2007)

--- The Dosing Protocol The study used a locally administered protocol, injecting near the joint rather than systemic subcutaneous injection

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P., Freund, S

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