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Wegovy and other GLP-1 receptor agonists have been associated with modest increases in resting heart rate (approximately 2-3 beats per minute on average according to the SmPC, though some individuals may experience larger increases)
& Proneth, B
We had assumed it was a consequence of losing weight but this seems to suggest theres a separate pathway. We dont know how those effects would play out in patients at a healthy weight, because they werent part of the study so it doesnt mean that semaglutides should be considered as a treatment for anyone with heart issues regardless of their weight
Second of all, this was the worst experience I have ever had with a prescribed medication
Not everyone experiences the same symptoms, which is why the condition can sometimes be difficult to recognize
GLP-1 agonism appears to directly reduce hepatic steatosis (fat buildup in the liver), and the glucagon component of retatrutide may add additional liver-specific benefit
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