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03 Stability, Storage & Multi-Dose Handling The 28-Day Rule for Punctured Multi-Dose Vials Unopened vials should be stored at controlled room temperature, 20C to 25C (68F to 77F)

Stomach acid is necessary to release vitamin B12 from food, and intrinsic factor is required for its absorption

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Discard sooner if: The solution becomes cloudy Contamination is suspected Lab SOPs specify a shorter timeframe Factors That Affect Stability Storage Conditions Direct sunlight, extreme heat, or freezing reduce shelf life

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Diets high in trans fats and low in micronutrients correlate with reduced motility and abnormal morphology