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Greater use of glucose by the glycolytic pathway has also been reported in mice in which mitochondrial -oxidation is impaired ( Reference Wicks, Vandanmagsar and Haynie 62 , Reference Tavecchio, Lisanti and Bennett 76 )

21,22,23,24 Lactylation also dictates the pathological process of neurological, cardiovascular, and ophthalmic diseases, as well as immunoinflammatory and metabolic dysfunction