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Besides this, it also switches the production of eumelanin (a dark brown color) to pheomelanin (a yellow-red color), which leads to the lightening of the skin

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Andersen et al., Low Activity Of Superoxide Dismutase and High Activity of Glutathione Reductase in Erythrocytes from Centenarians, Age Ageing 27 (5), 643648 (1998)

Reactivation of cAMP pathway by PDE4D inhibition represents a novel druggable Axis for overcoming tamoxifen resistance in ER-positive breast cancer