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In placebo-controlled trials evaluating semaglutide used as monotherapy and as an add-on to insulin glargine, treatment with semaglutide resulted in statistically significant reductions in glycosylated HbA 1C of 1.2% to 1.4% and 1.1% to 1.6% respectively, compared with placebo

It works by: Slowing gastric emptying , which prolongs the feeling of fullness after meals Acting on appetite centres in the brain to reduce hunger and food cravings Improving insulin secretion in response to elevated blood glucose levels Reducing glucagon secretion , which helps regulate blood sugar Wegovy is administered as a once-weekly subcutaneous injection

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