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The pooled results showed that semaglutide reduced MACECV death, nonfatal myocardial infarction, and nonfatal strokewith a hazard ratio of 0.83, representing a 17% relative risk reduction and low heterogeneity (I = 25%)

Our study demonstrated that NaB upregulated hepatic GLP-1R expression by inhibiting HDAC2, which improved hepatic GLP-1 sensitivity and prevented NAFL disease progression (Fig

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