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It means that even if a patch contains a clinically studied ingredient, that ingredient may not be reaching the bloodstream in any meaningful amount (7)

Buckley ST, Schele SG, Kirk RK, Knudsen LB

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Liu M, Tandorost A, Moludi J, Dey P

coli BL21pLysS with each allele and subsequently individually purified recombinant yeaW and yeaX from bacterial lysates (Figure 3B,C)