The trial currently has almost 10,000 patients enrolled and is expected to assess a composite MACE endpoint consisting of cardiovascular (CV) death, non-fatal myocardial infarction, or non-fatal stroke in patients with T2D as is expected to readout in July 2024 (NCT03574597)
Additionally, the significant weight loss achieved with GLP-1 receptor agonists leads to changes in body composition, fluid distribution, and metabolic rate, all of which can influence cardiovascular hemodynamics
The Semaglutide Treatment Effect in People with Obesity and Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus (STEP-HFpEF DM) trial demonstrated that semaglutide significantly reduced body weight and improved HF-related symptoms and physical limitations in people with obesity-related HF with preserved ejection fraction and type 2 diabetes mellitus [93]
Meanwhile, integrating the microbiome and transcriptome found that Bacteroidetes , Lachnospiracea incertaesedis and Clostridium XIVa were enriched in HCC patients, and their changes in the tumor immune microenvironment through serum bile acids may be important factors associated with liver cancer burden and poor clinical outcomes (93)
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