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GLP-1RAs (e.g., exenatide and liraglutide) appear effective in modulating BAT thermogenesis and browning, controlling food intake, and increasing energy expenditure through the action on the hypothalamic AMPK pathway, with clinically significant effects

The MHRA has approved these medications for specific indications, and NICE guidelines recommend their use in adults with type 2 diabetes who meet certain criteria (NG28)

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Long-acting reversible contraceptives (IUDs, implants) are unaffected because they are not oral

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10.2337/diabetes.53.5.1187 [DOI] [PubMed] [Google Scholar] 125.Jensen L, Helleberg H, Roffel A, van Lier JJ, Bjrnsdottir I, Pedersen PJ, et al