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[oai_citation:4PubMed]( [oai_citation:5PMC]( 4) Growth-hormone receptor (GHR) expression in tendon fibroblasts Gene-expression and protein studies found dose- and time-dependent up-regulation of GHR

The Broad Institute gene-expression dataset documents changes across 4,192 human genes following GHK exposure

Some people may not have any adverse effects at all, while others deal with ongoing problems

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However, because they stimulate GH release and activate the ghrelin receptor , certain adverse effects can occur, particularly with higher doses or prolonged use

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