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excess melanin formation will cause problems such as hyperpigmentation, dark patches, and uneven skin tone

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Schmutzler C, Mentrup B, Schomburg L, Hoang-Vu C, Herzog V, Khrle J (2007) Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3

(Citation2008) demonstrated that Se enhances the expression of some ethylene- and jasmonic acid-responsive genes, and in S assimilation it activates one of the downstream pathways enhancing sulfate reduction