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Discussion : This report presents the first Bulgarian family with HAE-PLG, detailing the clinical course, treatment challenges, and explored modalities in the context of limited diagnostic tools to identify HAE-nC1-INH and rare genetic variants linked to HAE

explored the direct intradiscal injection of antibodies against NGF or NGF receptors (trkA and p75 NTR ) to suppress downstream CGRP neurotransmitter expression in projecting DRGs

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This plan may be to gradually taper the dosage of semaglutide while introducing alternative strategies for appetite management and blood sugar control