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GLP-1 receptor agonists Liraglutide: Liraglutide has shown anti-inflammatory properties

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The differential microbes in the model group compared to the control group included Cetobacterium , Corynebacterium , Jeotgalicoccus , Lactobacillus , Methylobacterium , Olsenella , Petrimonas , Rothia, and Streptococcus

91 In addition, lactylation at K91 of TFEB inhibits its interaction with the E3 ubiquitin ligase WWP2, leading to reduced ubiquitination and proteasomal degradation of TFEB, thereby resulting in enhanced TFEB activity