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Updated July 2026 Author: Allison Jones, FNP Medically reviewed by Dr

This decision requires individualized clinical assessment, not self-management

Primary Cellular Pathways Folate-AICAR-AMPK Pathway Activation Research has demonstrated that MOTS-c directly inhibits the folate cycle and its tethered de novo purine biosynthesis, leading to accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), a well-characterized AMPK activator

1 Diabetes and Endocrine, Liverpool Hospital, Liverpool, Australia, 2 Diabetes and Endocrine, Western Sydney University, Campbelltown, Australia

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Selective cytotoxicity of the NAMPT inhibitor FK866 toward gastric cancer cells with markers of the epithelial-mesenchymal transition, due to loss of NAPRT