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Persistent organic pollutants such as PBDEs and PCBs showed associations with reduced serum thyroid hormone levels, altered expression of TH-responsive genes, modifications in thyroid hormone-binding proteins, and an elevated likelihood of hypothyroidism (66, 71)

Nevertheless, in contrast to the vast knowledge collected about the detoxification function of GSTs, the understanding of their role in endogenous plant processes and about their metabolic substrates had been still far from complete (Marrs, 1996

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Subcutaneous once weekly