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doi: 10.3389/fphar.2021.663325 269 DengXLiYJiangLXieXWangX

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These experiments demonstrated that the relatively low dose of MK-801, required for achieving a synergistic weight loss by the conjugate, does not affect the body temperature after 14 days of repeated dosing, as none of the treatment groups displayed different core temperature compared with the vehicle-treated mice (Extended Data Fig

& Pan, J

The encouraging news is that this process is often reversible

Most researchers see reversal within two to four weeks