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Adding semaglutide to naltrexone has not yet been formally evaluated in large randomized controlled trials, meaning efficacy and safety in this specific pairing remain largely theoretical

Tests carried out with GLP-1 had so far proved disappointing, leading many to question its role in glucose metabolism

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While at Lilly, DiMarchi had helped to synthesise GLP-1 for Suad Efendic, a leading clinical diabetes researcher from Yugoslavia based at Karolinska University in Stockholm, Sweden

In Eli Lilly's pivotal Phase 3 ATTAIN clinical trialsthe studies that led to FDA approvalparticipants taking orforglipron achieved average body weight reductions of approximately 7.9% to 8.7% over 36 to 40 weeks, depending on the dosing