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It is notable that in the cryo-EM conditions here, ipratropium did not induce occlusion like with the native substrate carnitine

10.3390/nu16111580 47 GallelliG.CioneE.SerraR.LeoA.CitraroR.MatricardiP.et al (2020)

The Antidepressant effects of an mGlu2/3 receptor antagonist and ketamine require AMPA receptor stimulation in the mPFC and subsequent activation of the 5-HT neurons in the DRN