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Based on spectroscopic studies it was suggested that His forms a ternary complex with CuHSA 34 , however, a direct [ 14 C]His binding assay by using ultrafiltration showed that His interaction with CuHSA could be only transient 8

doi: 10.1097/MD.0000000000026295 235 HolstJJ

When a single laboratory performs all testing, there is an inherent risk of systematic bias

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Response to supplementation: In some cases, a therapeutic trial of L-carnitine supplementation is used diagnostically