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The SURPASS trial indicated a higher incidence of injection site responses than placebo, which were mild to moderate ( Gastrointestinal events were the most common treatment-emergent ADEs in several clinical trials, and most were mild to moderate in intensity ( We also identified unexpected signals, such as impaired gastric emptying (n = 181, ROR 16.60, PRR 16.57, IC 3.89, EBGM 14.81), abnormal gastrointestinal sounds (n = 37, ROR 5.28, PRR 5.27, IC 2.35, EBGM 5.11), and projectile vomiting (n = 22, ROR 8.09, PRR 8.09, IC 2.94, EBGM 7.67)

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(A) Risk of bias summary: review authors judgments about each risk of bias item for each included study

It is also possible that glycaemic targets were achieved at lower doses, discouraging the need for dose escalation

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