Documented side effects are usually mild to moderate: Injection-site pain, redness, or bruising Flushing Increased heart rate Nausea or gastrointestinal upset Headache Urinary changes or a fishy body odor at higher choline doses Because these are compounded products, sterile technique, pharmacy sourcing, and formulation verification matter
It also shrinks tumors
C9775 Revascularization, endovascular, open or percutaneous, tibial/peroneal artery(ies)
For detailed strategies, see our [guide to preventing muscle loss on GLP-1 medications](/guides/glp1-muscle-loss-prevention-semaglutide-tirzepatide-guide)
Semaglutide reduces stomach acid production as a secondary effect of delayed gastric emptying
It has poor metabolic stability, a short half-life in circulation, and limited bioavailability when administered systemically