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This has led Russell12 to redefine FMS as Central Allodynia and Donaldson et al to call FMS a type of CNS Myalgia.27 This presence of CNS dysfunction, fibro-fog, memory problems, lowered pain threshold, sleep disorders, and other brain-processing difficulties is what appears to be the major differentiating factor between the categories of Classic FMS and Pseudo FMS

The discussion considers several potential mechanisms for DSIPs observed benefits suggesting DSIP could be associated with the rescuing of neurons in motor cortex and subcortical structures involved in motor control