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1 Introduction Alzheimer's disease (AD) remains leading cause of cognitive impairment and dementia in older persons (aged 65 years) throughout the world ( The conventional amyloid-centric perspective of Alzheimer's disease emphasizes the metabolic dysfunction of amyloid precursor protein (APP) and the resultant aggregation of amyloid-beta (A)

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Three critical and emerging regulatory axes have been identified as core determinants of C

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