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In LEADER, there was a higher, albeit non-significant, rate of adverse retinal events with liraglutide compared with placebo (HR 1.15, 95% CI 0.871.52
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By acting on the central nervous system (CNS), GLP-1s specifically activate receptors in key brain regions, like the hypothalamus, to regulate energy balance
doi:10.1007/s00441-019-03016-8 Chang CH, Tsai WC, Hsu YH, Pang JH