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The problem with prolonged caloric deficit is that metabolic adaptation your body downregulates energy expenditure over time to resist the deficit

Matsuda M, et al

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, NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-B pathway after intracerebral hemorrhage in mice, Springer Science and Business Media LLC, Oct