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133 Whilst the available evidence suggests that NAC is safe during pregnancy, in view of the scarcity of data, NAC supplementation should only be recommended to pregnant women by a suitably qualified and experienced healthcare professional

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In rabbit models, intra-articular injection of scAAV2 encoding interleukin-1 receptor antagonist (IL-1Ra) yielded sustained therapeutic protein expression in both inflamed and normal joints for at least two weeks, with minimal immune activation or joint pathology (178)

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