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This is a normal pattern related to how the medication moves through the body

In their correspondent colors, AUCs and their 95% confidence intervals are displayed as text

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There are some data to suggest that insulin resistance also occurs in PD [70], however, this is controversial since systemic insulin resistance is not present in de novo, medication-free PD patients [71], and brain insulin resistance is not present in cognitively normal PD cases [72]

Campdesuner, V., Teklie, Y., Alkayali, T., Pierce, D., & George, J

Substancje podawane drog iniekcji podskrnej, niebdce lekami lub wyrobami medycznymi, s dopuszczone do sprzeday na terenie Unii Europejskiej jako materia referencyjny