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To approach the efficacy of BS, dual and triple agonists combining GLP-1 with other entero-pancreatic hormones with complementary actions, including glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG) and amylin are currently under development [15]

261 In addition to tetramer dissociation, a recent study using the Ser52Pro TTR variant identified a distinct amyloidogenesis pathway, wherein proteolytic cleavage of native TTR also contributes to amyloid formation in vivo

doi: 10.1371/journal.pone.0214412

Depression, a widespread mental health challenge, frequently demonstrates minimal effectiveness with traditional antidepressants, underscoring the demand for innovative treatments

Modern lifestyle factors accelerate this drop even further

Cutaneous symptoms are currently being managed with metronidazole cream and oral minocycline