gallbladder glp-1 Glucagon-like peptide-1 receptor agonist use may up risk for gallbladder, biliary diseases glp 1 and gallbladder issues

For a broader overview, see the AJMC article on oral peptides

Two reactions involving glucose metabolites catalyse the reduction of NADP+ to NADPH: glucose 6-phosphate dehydrogenase, forming 6-phosphogluconate, and phosphogluconate dehydrogenase, which yields the 5-carbon sugar ribulose 5-phosphate, liberating carbon dioxide from carbon-1 of the substrate

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Christensen MB, Lund AB, Jrgensen NR, Holst JJ, Vilsbll T, Knop FK (2020) Glucose-dependent insulinotropic polypeptide (GIP) reduces bone resorption in patients with type 2 diabetes

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this is a normal occurrence for this research compound