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Here, diet-induced obesity has been shown to increase IL-6 expression and promote the polarization of macrophages into M2-like macrophages, enhancing the production of CC-chemokine-ligand (CCL) 20

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Studies show oral administration at 50mg produces peak plasma levels of 512 ng/mL, while subcutaneous injection at 2mg produces 85110 ng/mL a 40-fold difference in systemic exposure per milligram administered