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As clinical data for both anti-PCSK9 antibodies and GLP-1 analogue molecules are widely available, we used PK-PD modelling to determine the appropriate potency at human GLP-1R for the fusion molecule that should deliver robust glucose control without inducing non-manageable GLP-1 driven adverse events at exposure levels able to efficiently neutralize PCSK9

We provide both simulation results, obtained with scalable continuous constant p H molecular dynamics (C p HMD) simulations, and experimental evidence (NMR, DOSY, and DLS) to support this unique permeation mechanism

10.1111/nyas.13008 Ann

Improved Insulin Sensitivity: Insulin resistance is a key feature of metabolic syndrome and is associated with increased mortality

Some procedures can remove the damaged pancreatic tissue