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Subsequent clinical success demonstrated that these liabilities could be mitigated through slower absorption kinetics, extended dosing intervals, and careful titration, ultimately allowing the beneficial metabolic effects to dominate the riskbenefit profile ( 3.1 Enabling technologies in modern peptide pharmacology One of the most important developments reshaping peptide drug discovery has been the widespread adoption of long-acting peptide design strategies

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Others include glucose-dependent insulinotropic polypeptide (GIP), ghrelin, peptide YY (PYY) and pancreatic polypeptide (PP) (1)