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I think they have good rationale for doing that

Risk of miscarriage and birth defects Both semaglutide and tirzepatide have been shown to cause miscarriage and birth defects in pregnant lab animals (rats and rabbits) at doses equivalent to what is used for humans

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Zambrano S, Blanca AJ, Ruiz-Armenta MV, et al

cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in patients with heart failure

We examined alterations in oxygen metabolism during the pathogenesis of HACE, in which the activation and expression levels of ROS, HIF-1, Nrf2, NF-B, NLRP3 and AQP4 are critical factors