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Preclinical research shows that some of these receptors are found in the area postrema , a part of the brainstem often called the vomiting center. When you take semaglutide or tirzepatide, this center lights up, signaling to your body that its time to feel nauseous

Treatment discontinuation due to gastrointestinal events occurred in a minority of patients, and overall, serious adverse events were similar to those with the placebo

Combination antithrombotic therapy, including GLP-1 receptor agonists, further exacerbates this risk [142]