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When Eli Lilly asked the FDA to approve Zepbound, it provided a list of potential side effects based on clinical trials it conducted

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The minimum effective threshold appears to be 1.2 grams per kilogram of body weight per day

Regarding the clinical outcomes, there was no significant difference in the length of hospital stay between the two groups ( p = 0.399)

while more recent studies have applied statistical models of increasing complexity and sophistication to this challenge