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Iron dysregulation is a hallmark of ferroptosis, where excess intracellular iron promotes the Fenton reaction, generating hydroxyl radicals and amplifying oxidative stress

Unfortunately, while mechanistically distinct treatment options are available, including monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotoninnorepinephrine reuptake inhibitors (SNRIs), and atypical antidepressants (e.g., bupropion, mirtazapine), inadequate or partial response is still common in MDD treatment [13, 14, 17]

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The mistake that derails more combo attempts than any other is impatience disguised as ambition