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Since the first GLP-1RA, exenatide, was approved by the US Food and Drug Administration (FDA) in 2005, several GLP-1RAs have entered the clinic, including liraglutide (2009), lixisenatide (2013), dulaglutide (2014), and semaglutide (2017) 285

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10.1021/jm950005k J

Compounded tirzepatide offers a substantially lower price point, though availability fluctuates based on regulatory status

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The FDA scientists are set to present their conclusions next month at an FDA advisory committee meeting that will assess whether to allow compounding pharmacies to produce seven different peptides