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Repeated restraint stress induces oxidative damage in rat hippocampus

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For example, NRF2 activation was found to protect cells against ionizing radiation toxicity and confer radioresistance [98]

Although most of NAPQI is formed in the liver, the kidney also metabolizes APAP to the toxic metabolite and releases cysteine conjugate of APAP into the bile and blood for further elimination in urine [9]

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Among its several metabolic functions in cells, the main one is the potential to act as an endogenous antioxidant agent