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The daily dose can be increased to 6 mg, if clinically indicated

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Some of the first studies discussing application of IM-MS include identification and mobility of ions in a Townsend discharge by time-resolved mass spectrometry (McAfee Jr and Edelson, 1963), analysis of the ionic polymerization of ethylene at near atmospheric pressures (Kebarle and Hogg, 1965), and analysis of ammonium ions produced by the alpha radiolysis of ammonia and their solvation in the gas phase by ammonia and water molecules (Hogg and Kebarle, 1965)