GLP-1 receptor agonists (GLP-1RAs) increase GLP-1 levels by 10 times or more and exert several pharmacological actions, including appetite-suppressant effects and delayed gastric emptying
Because GLP-2 acts through subepithelial myofibroblasts, which are the same cell population implicated in intestinal fibrogenesis, the risk-benefit profile of GLP-2 agonism may differ substantially between mucosal UC, inflammatory ileal CD, and stricturing or penetrating CD phenotypes, and this phenotypic stratification should be a required feature of future trial design
Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention
If youre concerned about digestive side effects or have a history of gastrointestinal issues, discuss these with your doctor before starting treatment
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