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Furthermore, APOE4 is associated with a decrease in the basal membrane area and an increase in thrombin concentrations in the vessel walls [144, 153]

The mechanistic pathways described are largely inferred from preclinical models, in vitro experiments, and observational human studies

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(PubMed) Calvani M, Benatti P, Mancinelli A, et al

7 Conclusion This review underscores the central role of OS in the pathogenesis of diabetic neuropathy (DN) and highlights the therapeutic application of natural antioxidants

O primeiro frmaco desta classe aprovado para uso teraputico em 2006 pelo FDA foi a sitaglipitina, obtida aps uma srie de otimizaes estruturais a partir de ligantes identificados por triagem robotizada de alto rendimento